The mechanism of action is due to its antioxidant and membrane action. The drug inhibits lipid peroxidation, superoxide dismutase activity of the enzyme increases, increases the ratio of lipid in the cell membrane protein, membrane stabilizing blood cells, decreases blood viscosity and increases its fluidity.Modulates the activity of membrane-bound enzymes (kaltsiynezavisimoy phosphodiesterase, adenylate cyclase, acetylcholinesterase) receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps to preserve the structural and functional organization of biological membranes, transport of neurotransmitters and improve synaptic transmission. It increases deca durabolin side effects the content of dopamine in the brain. Causes increased compensatory activation of aerobic glycolysis and decreased inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with increasing the content of ATP and creatine phosphate, activation energosinteziruyuschih mitochondrial functions stabilize cell membranes.
It has a wide spectrum of pharmacological activity: it increases the body’s resistance to stress, exhibit anxiolytic effect without accompanied by drowsiness and muscle relaxant effect; has nootropic properties improves memory, facilitates the learning processes, improves concentration and mental performance; It has anticonvulsant effect; shows antioxidant properties and antihypoxic; It improves concentration and performance; It weakens the toxic effect of alcohol.
The value of the maximum concentration (Cmax) in plasma levels of the drug when administered intramuscularly – 0,3-0,58 hour Cmax when administered intramuscularly at a dose of 400-500 mg -. 2.5-4 ug / ml. Quickly spread to organs and tissues. The half-life (T1 / 2) and mean residence time of the drug in the body by intramuscular injection -. 0.7-1.3 hours is metabolized in the liver by glyukuronirovaniya. Identified metabolites 5: 3-hydroxypyridine phosphate in the image of the liver, with the participation of alkaline phosphatase splits into phosphoric acid and 3-oxy-pyridin; 2nd metabolite – a pharmacologically active and is formed in large quantities and is found in urine at 1-2 days after injection; 3rd deduces in large amounts in the urine; 4 th and 5 th – glyukuronkonyugaty. The drug is excreted in the urine primarily as metabolites (50% for 12 hours) and in small amounts – unchanged (0.3% in 12 hours). The most extensively excreted within the first 4 hours after ingestion. Performance in the urine excretion of unchanged drug and metabolites have considerable individual variability.
- acute disorders of cerebral circulation on ischemic type (in the complex therapy)
- vascular dystonia
- anxiety in neurotic and neurosis-like states
- mild cognitive impairment of vascular genesis
- age-related cognitive decline in the elderly (memory disorders, orientation, concentration)
- asthenic conditions, under extreme (stress) factors
- abstinence syndrome in alcoholism with a predominance of neurosis and vegetative-vascular disorders
- acute intoxication by antipsychotic drugs
Acute liver and / or kidney failure, increased individual sensitivity to the drug. Children’s age, pregnancy, breast-feeding – due to lack of data.
Allergic deca durabolin side effects diseases in history (for parenteral administration).
Dosing and Administration
Assign intramuscularly or intravenously (bolus or infusion). Doses picked individually. When infusion method of administering the drug should be diluted in 0.9% sodium chloride solution. Started treatment with doses of 50-100 mg, 1-3 times a day, gradually increasing the dose to produce a therapeutic effect. Chip drug is administered slowly over 5-7 minutes, drip – at a rate of 40-60 drops per minute. The maximum daily dose should not exceed 800 mg.
In case of acute cerebral circulatory disorders used in the treatment in the first 2-4 days, intravenous infusion of 200-300 mg 1 time a day, followed by intramuscular injection of 100 mg 3 times a day. The duration of treatment is 10-14 days. In vascular encephalopathy in a phase of decompensation of the drug should be administered by intravenous bolus or infusion at a dose of 100 mg 2-3 times a day for 14 days. Then, the drug is administered by intramuscular injection of 100 mg 2-3 times a day for the next 2 weeks. For vascular encephalopathy drug prevention course is administered intramuscularly at a dose of 100 mg 2 times a day for 10-14 days. For mild cognitive impairment, age-related cognitive decline and anxiety disorders, drug use intramuscularly at a dose of 100-300 mg daily for 14-30 days.
In the vegetative-vascular dystonia, asthenic conditions, neurotic and neurosis-like states – intramuscular injection of 50-400 mg / day for 14 days. When alcohol withdrawal syndrome drug is administered at a dose of 100-200 mg intramuscularly 2-3 times a day or intravenously 1-2 times a day for 5-7 days.
In acute intoxication antipsychotic drug agent is administered intravenously at a dose of 50-300 mg day for 7-14 days.
For parenteral administration (especially intravenously): dryness of the oral mucosa, “metallic” taste in the mouth, feeling of “bottled heat” in the body, bad breath, sore throat and discomfort in the chest, feeling short of breath (as a rule, associated with excessively high rate of introduction and are of short duration); long-term use – nausea, flatulence; sleep disturbances (drowsiness or disturbance of sleep).
Symptoms: Sleep disturbance (insomnia, in some cases – drowsiness). Treatment usually is not required – the symptoms disappear on their own within a day. In severe cases of insomnia are advised to take sleeping pills. Symptoms: When administered intravenously, – a slight and short-term (up to 1.5-2 hours) increase in blood pressure. Treatment: In case of excessive increase in blood pressure – antihypertensive drugs for blood pressure control.
Interaction with other drugs
The drug Medomeksi compatible with psychotropic drugs; It enhances the action of benzodiazepine anxiolytics, antiparkinsonian and carbamazepine; enhances the effect of nitrates.
During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Solution for intravenous or intramuscular injection of 50 mg / ml.
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2 ml or 5 ml in neutral glass ampoules.
5 vials in blisters of PVC film and deca durabolin side effects aluminum foil printing lacquer or flexible packaging based on aluminum foil, or without foil.
By one or two blisters (foil or non-foil) together with instructions for use of the drug, with a knife or lancet ampoule in a pile of cardboard.
for 20, 50 or 100 contour of cellular packaging foil, together with 10, 25 or 50 instructions use of the drug, respectively, knives or bifurcated ampoule in a box made of cardboard or corrugated cardboard box (for the hospital).
When packing vials of rings or dots fracture knives or scarifiers ampoule do not invest. steroiden kaufen
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